High Fructose Corn Syrup (HFCS) doesn’t affect satiety (feeling of fullness) any different than other caloric sweeteners. Recent studies have compared HFCS’s affect on appetite with other sugars such as sucrose (table sugar) and found no differences.
High fructose corn syrup is produced by processing corn starch, which changes its sugars from glucose to fructose. The sweetener became a popular replacement for table sugar (sucrose) in the 1980s because it is less expensive. When you consider how many products use sweeteners, you can only imagine the financial savings for soda and food manufactures. At the end of the day, with all things equal (calories burned and consumed, meal spacing, type of food or drink, etc.) except the caloric sweetener used in your foods/drink, there would be little to no affect on your sense of fullness no matter which one you choose.